Project Title: Personalized implants made by biodegradable magnesium-based alloys with modified surface for bone tissue regeneration

Project Acronym: MagReBone

Project Code: PN-IV-P1-PCE-2023-1452

Contract Number: 95PCE/01.07.2025

Contractor: National University of Science and Technology POLITEHNICA Bucharest

 Contract Start Date: 01.07.2025

Contract End Date: 30.06.2028

Abstract

One of the most important concepts in the material science and engineering field is represented by new biomaterials used in dedicated implant manufacture for medical sciences that can generate a microenvironment adequate for cellular differentiation in a controlled manner to regenerate the damaged or absent tissue.

The project’s main objective consists of designing, manufacturing, characterizing, and testing new configurations of bioactive and biodegradable Mg-based alloys implant with anatomical geometry used for critical-sized bone defect treatment. In order to achieve the project objectives, we establish a work strategy, based on the previous experience and results obtained. The main elements of originality and innovation of the proposed project consist of the fact that the implants, that will be developed, will have a similar geometry to that of the human bone, and their shape will be anatomically adapted. One innovative approach is related to the development of a comprehensive methodology for optimizing the design for an Mg-based alloy implant starting from personalized medical imagistics, using artificial intelligence and inverse dynamics analysis.

Expected Results

Research and financial reports for the intermediate and final stages.

Audit reports corresponding to each stage.

Patent application.

Project website.

AI software for segmentation; Innovative procedures for the identification and segmentation of bone defects; 3D models; Innovative implant design; Innovative bioactive coating design; Optimized implant design.

Metal molds obtained by 3D printing, prototype implants made of Mg-based alloys. Experimental samples for characterization and testing.

Prototype implants made of Mg-based alloys with bioactive ceramic coating.

Experimental samples for characterization and testing.

Analysis report on biodegradation by electrochemical testing.

Analysis report on surface properties.

Analysis report on biodegradation by immersion tests.

Report on in vitro biocompatibility.

Report on in vivo biocompatibility.

Dissemination reports of research results (articles, conference presentations).

Work Plan

Stage I / 31.12.2025 – Design of the Mg-based alloy implants.

Stage II / 30.12.2026 – Manufacturing the Mg-based alloys implants. Microstructural characterization of the magnesium-based alloy implants.

Stage III / 31.12.2027 – Evaluation of the mechanical properties, surface properties, and corrosion behavior using electrochemical methods.

Stage IV / 30.06.2028 – Evaluation of the biodegradation behavior through immersion tests of the magnesium-based alloy implants. In vivo evaluation of the biocompatibility of the Mg-based alloy implants.

Stage 1 Results

AI software for segmentations; Innovative procedures for the identification and segmentation of bone defects; 3D models; Innovative implant design; Innovative bioactive coating design; Database; Optimized implant design; Testing report.

Patent application for invention A/00592/04.12.2025, entitled: Metodă de elaborare a unui implant poros din aliaj de magneziu cu acoperire bioactivă

Project website: https://www.sim.upb.ro/index.php/magrebone/

1 ISI paper:

Suitability of Mg-Nd and Mg-Zn Alloys to Obtain Biodegradable Structures for Bone Defects, Veronica Manescu (Paltanea), Aurora Antoniac, Maria Cristina Moraru, Cosmin Mihai Cotrut, Iulian Antoniac, Sebastian Gradinaru, Alexandra Iulia Dreanca, Bogdan Sevastre, Romelia Pop, Flaviu Alexandru Tabaran, George Mihail Vlasceanu, Mariana Ionita, Marius Manole, J. Funct. Biomater. 2025, 16(11), 423; https://doi.org/10.3390/jfb16110423 (FI = 5,2)

 

2 oral presentations and 3 poster presentations at international conferences:

  1. Effect of the testing media on the degradation of magnesium-based alloys potentially used for bone defect treatments, Voicu Ioan Ștefan, Corneschi Iuliana, Antoniac Aurora, Pieptea (Popescu) Elena, Antoniac Iulian, Advances in 3OM: Opto-Mechatronics, Opto-Mechanics, and Optical Metrology and Photonics Technologies, 08-11 December 2025, Timisoara, Romania – POSTER PRESENTATION

  2. Biomaterials and Medical Devices in Tomorrow’s Healthcare, Iulian Vasile Antoniac, Advances in 3OM: Opto-Mechatronics, Opto-Mechanics, and Optical Metrology and Photonics Technologies, 08-11 December 2025, Timisoara, Romania – KEYNOTE PRESENTATION

  3. Evaluation of The Cellulose-Acetate-Based Composite Used as Coatings for Biodegradable Magnesium Implants, Streza Alexandru, Antoniac Aurora, Voicu Ioan Stefan, Paltanea (Manescu) Veronica, Popescu Elena, Antoniac Iulian, 4th INTERNATIONAL MATERIALS TECHNOLOGIES AND METALLURGY CONFERENCE, 02-03 October 2025, Istanbul, Turkey – ORAL PRESENTATION

  4. Mg-Zn biodegradable alloy as a suitable material for bone defect, Veronica Manescu (Paltanea), Iulian Antoniac, Aurora Antoniac, Alexandru Streza, Sebastian Gradinaru, Maria-Cristina Moraru, Bogdan Sevastre, Marius Manole, International Conference on Biomaterials & Regenerative Medicine BioREMED’2025, 16-18 October 2025, Oradea, Romania – POSTER PRESENTATION

  5. Structural modifications induced by plastic deformation in the case of biodegradable magnesium alloys from Mg-Zn-Mn-Ca system, Elena Pieptea (Popescu), Iuliana Corneschi, Aurora Antoniac, Nicolae Serban, Marian Miculescu, Iulian Antoniac, 6th International Conference on Powder Metallurgy & Advanced Materials, 29 October – 01 November 2025, Cluj-Napoca, Romania – POSTER PRESENTATION, The paper received the Best Poster Presentation Award.