{"id":6845,"date":"2025-12-09T13:56:52","date_gmt":"2025-12-09T11:56:52","guid":{"rendered":"https:\/\/www.sim.upb.ro\/?page_id=6845"},"modified":"2026-01-28T15:38:03","modified_gmt":"2026-01-28T13:38:03","slug":"magreboneen","status":"publish","type":"page","link":"https:\/\/www.sim.upb.ro\/index.php\/magreboneen\/","title":{"rendered":"MagReBoneEN"},"content":{"rendered":"\t\t
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Project Title: Personalized implants made by biodegradable magnesium-based alloys with modified surface for bone tissue regeneration<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Project Acronym:<\/strong> MagReBone<\/h3>

Project Code:<\/strong> PN-IV-P1-PCE-2023-1452<\/h3>

Contract Number:<\/strong> 95PCE\/01.07.2025<\/h3>

Contractor:<\/strong> National University of Science and Technology POLITEHNICA Bucharest<\/h3>

\u00a0<\/strong>Contract Start Date:<\/strong> 01.07.2025<\/strong><\/h3>

Contract End Date: 30.06.2028<\/strong><\/h3>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Abstract<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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One of the most important concepts in the material science and engineering field is represented by new biomaterials used in dedicated implant manufacture for medical sciences that can generate a microenvironment adequate for cellular differentiation in a controlled manner to regenerate the damaged or absent tissue.<\/h3>

The project’s main objective<\/strong> consists of designing, manufacturing, characterizing, and testing new configurations of bioactive and biodegradable Mg-based alloys implant with anatomical geometry used for critical-sized bone defect treatment. In order to achieve the project objectives, we establish a work strategy, based on the previous experience and results obtained. The main elements of originality and innovation of the proposed project consist of the fact that the implants, that will be developed, will have a similar geometry to that of the human bone, and their shape will be anatomically adapted. One innovative approach is related to the development of a comprehensive methodology for optimizing the design for an Mg-based alloy implant starting from personalized medical imagistics, using artificial intelligence and inverse dynamics analysis.<\/h3>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Expected Results<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Research and financial reports for the intermediate and final stages.<\/h3>

Audit reports corresponding to each stage.<\/h3>

Patent application.<\/h3>

Project website.<\/h3>

AI software for segmentation; Innovative procedures for the identification and segmentation of bone defects; 3D models; Innovative implant design; Innovative bioactive coating design; Optimized implant design.<\/h3>

Metal molds obtained by 3D printing, prototype implants made of Mg-based alloys. Experimental samples for characterization and testing.<\/h3>

Prototype implants made of Mg-based alloys with bioactive ceramic coating.<\/h3>

Experimental samples for characterization and testing.<\/h3>

Analysis report on biodegradation by electrochemical testing.<\/h3>

Analysis report on surface properties.<\/h3>

Analysis report on biodegradation by immersion tests.<\/h3>

Report on in vitro<\/em> biocompatibility.<\/h3>

Report on in vivo<\/em> biocompatibility.<\/h3>

Dissemination reports of research results (articles, conference presentations).<\/h3>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Work Plan<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Stage I \/ 31.12.2025<\/strong> \u2013 Design of the Mg-based alloy implants.<\/h3>

Stage II \/ 30.12.2026<\/strong> \u2013 Manufacturing the Mg-based alloys implants. Microstructural characterization of the magnesium-based alloy implants.<\/h3>

Stage III \/ 31.12.2027<\/strong> \u2013 Evaluation of the mechanical properties, surface properties, and corrosion behavior using electrochemical methods.<\/h3>

Stage IV \/ 30.06.2028<\/strong> \u2013 Evaluation of the biodegradation behavior through immersion tests of the magnesium-based alloy implants. In vivo<\/em> evaluation of the biocompatibility of the Mg-based alloy implants.<\/h3>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Project team members:<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Vasile Iulian Antoniac – University Professor, Project director
Lucian Gruionu – University Professor, Scientific Researcher I
Florin Miculescu – University Professor, Scientific Researcher I
Voicu Ioan Stefan – University Professor, Scientific Researcher I
Marian Miculescu – University Professor, Scientific Researcher I
Aurora Antoniac, Scientific Researcher
Robert Bololoi, Scientific Researcher
Alina Robu, Postdoctoral Researcher
Veronica Paltanea, PhD Student
Vacant position, Postdoctoral Researcher<\/h3>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Stage 1 Results<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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AI software for segmentations; Innovative procedures for the identification and segmentation of bone defects; 3D models; Innovative implant design; Innovative bioactive coating design; Database; Optimized implant design; Testing report.<\/h3>

Patent application for invention A\/00592\/04.12.2025, entitled: Metod\u0103 de elaborare a unui implant poros din aliaj de magneziu cu acoperire bioactiv\u0103<\/em><\/h3>

Project website: https:\/\/www.sim.upb.ro\/index.php\/magrebone\/<\/h3>

1 ISI paper:<\/h3>

Suitability of Mg-Nd and Mg-Zn Alloys to Obtain Biodegradable Structures for Bone Defects,<\/em> Veronica Manescu (Paltanea), Aurora Antoniac, Maria Cristina Moraru, Cosmin Mihai Cotrut, Iulian Antoniac, Sebastian Gradinaru, Alexandra Iulia Dreanca, Bogdan Sevastre, Romelia Pop, Flaviu Alexandru Tabaran, George Mihail Vlasceanu, Mariana Ionita, Marius Manole, J. Funct. Biomater<\/em>. 2025, 16(11), 423; https:\/\/doi.org\/10.3390\/jfb16110423<\/a> (FI = 5,2)<\/h3>

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2 oral presentations and 3 poster presentations at international conferences:<\/h3>

  1. Effect of the testing media on the degradation of magnesium-based alloys potentially used for bone defect treatments<\/em>, Voicu Ioan \u0218tefan, Corneschi Iuliana, Antoniac Aurora, Pieptea (Popescu) Elena, Antoniac Iulian, Advances in 3OM: Opto-Mechatronics, Opto-Mechanics, and Optical Metrology and Photonics Technologies<\/em>, 08-11 December 2025, Timisoara, Romania \u2013 POSTER PRESENTATION<\/strong><\/h3><\/li>

  2. Biomaterials and Medical Devices in Tomorrow\u2019s Healthcare<\/em>, Iulian Vasile Antoniac, Advances in 3OM: Opto-Mechatronics, Opto-Mechanics, and Optical Metrology and Photonics Technologies<\/em>, 08-11 December 2025, Timisoara, Romania \u2013 KEYNOTE PRESENTATION<\/strong><\/h3><\/li>

  3. Evaluation of The Cellulose-Acetate-Based Composite Used as Coatings for Biodegradable Magnesium Implants<\/em>, Streza Alexandru, Antoniac Aurora, Voicu Ioan Stefan, Paltanea (Manescu) Veronica, Popescu Elena, Antoniac Iulian, 4th INTERNATIONAL MATERIALS TECHNOLOGIES AND METALLURGY CONFERENCE,<\/em> 02-03 October 2025, Istanbul, Turkey \u2013 ORAL PRESENTATION<\/strong><\/h3><\/li>

  4. Mg-Zn biodegradable alloy as a suitable material for bone defect,<\/em> Veronica Manescu (Paltanea), Iulian Antoniac, Aurora Antoniac, Alexandru Streza, Sebastian Gradinaru, Maria-Cristina Moraru, Bogdan Sevastre, Marius Manole, International Conference on Biomaterials & Regenerative Medicine BioREMED\u20192025, <\/em>16-18 October 2025, Oradea, Romania \u2013 POSTER PRESENTATION<\/strong><\/h3><\/li>

  5. Structural modifications induced by plastic deformation in the case of biodegradable magnesium alloys from Mg-Zn-Mn-Ca system<\/em>, Elena Pieptea (Popescu), Iuliana Corneschi, Aurora Antoniac, Nicolae Serban, Marian Miculescu, Iulian Antoniac, 6th International Conference on Powder Metallurgy & Advanced Materials<\/em>, 29 October – 01 November 2025, Cluj-Napoca, Romania \u2013 POSTER PRESENTATION<\/strong>, The paper received the Best Poster Presentation Award.<\/em><\/h3><\/li><\/ol>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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    Cognitive and Socio-Economic Impact<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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    The project’s cognitive impact is reflected in the development of advanced, interdisciplinary knowledge at the interface of biomedical engineering, materials science, artificial intelligence, and regenerative medicine.
    Stage I contributed to the development of innovative methods for the identification and segmentation of bone defects using artificial intelligence, as well as to the creation of 3D models and advanced design concepts for biodegradable magnesium-based alloy implants with anatomically adapted geometry and bioactive coatings. The results obtained extend the current state of knowledge in the field of resorbable implants and personalized medical devices, supported by the creation of a dedicated database and the submission of a patent application, which confirms the originality and innovative character of the proposed solutions.
    From a socio-economic perspective, the project has the potential to generate significant benefits for public health. Biodegradable magnesium-based implants with anatomically adapted geometry and bioactive coatings can reduce the need for secondary surgical interventions to remove implants, accelerate bone healing, and decrease the risk of post-operative complications. These advantages lead to reduced hospitalization time, lower treatment costs, and shorter recovery periods for patients with critical-sized bone defects.
    The project’s scientific impact will be highlighted through the dissemination of its results in peer-reviewed journals. At the same time, one PhD student and one postdoctoral researcher will acquire advanced research skills, thereby consolidating their professional profiles and increasing their international visibility.<\/h3>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

    Project Title: Personalized implants made by biodegradable magnesium-based alloys with modified surface for bone tissue regeneration Project Acronym: MagReBone Project Code: PN-IV-P1-PCE-2023-1452 Contract Number: 95PCE\/01.07.2025 Contractor: National University of Science and Technology POLITEHNICA Bucharest \u00a0Contract Start Date: 01.07.2025 Contract End Date: 30.06.2028 Abstract One of the most important concepts in the material science and engineering […]<\/p>\n","protected":false},"author":4,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"ocean_post_layout":"","ocean_both_sidebars_style":"","ocean_both_sidebars_content_width":0,"ocean_both_sidebars_sidebars_width":0,"ocean_sidebar":"","ocean_second_sidebar":"","ocean_disable_margins":"enable","ocean_add_body_class":"","ocean_shortcode_before_top_bar":"","ocean_shortcode_after_top_bar":"","ocean_shortcode_before_header":"","ocean_shortcode_after_header":"","ocean_has_shortcode":"","ocean_shortcode_after_title":"","ocean_shortcode_before_footer_widgets":"","ocean_shortcode_after_footer_widgets":"","ocean_shortcode_before_footer_bottom":"","ocean_shortcode_after_footer_bottom":"","ocean_display_top_bar":"default","ocean_display_header":"default","ocean_header_style":"","ocean_center_header_left_menu":"","ocean_custom_header_template":"","ocean_custom_logo":0,"ocean_custom_retina_logo":0,"ocean_custom_logo_max_width":0,"ocean_custom_logo_tablet_max_width":0,"ocean_custom_logo_mobile_max_width":0,"ocean_custom_logo_max_height":0,"ocean_custom_logo_tablet_max_height":0,"ocean_custom_logo_mobile_max_height":0,"ocean_header_custom_menu":"","ocean_menu_typo_font_family":"","ocean_menu_typo_font_subset":"","ocean_menu_typo_font_size":0,"ocean_menu_typo_font_size_tablet":0,"ocean_menu_typo_font_size_mobile":0,"ocean_menu_typo_font_size_unit":"px","ocean_menu_typo_font_weight":"","ocean_menu_typo_font_weight_tablet":"","ocean_menu_typo_font_weight_mobile":"","ocean_menu_typo_transform":"","ocean_menu_typo_transform_tablet":"","ocean_menu_typo_transform_mobile":"","ocean_menu_typo_line_height":0,"ocean_menu_typo_line_height_tablet":0,"ocean_menu_typo_line_height_mobile":0,"ocean_menu_typo_line_height_unit":"","ocean_menu_typo_spacing":0,"ocean_menu_typo_spacing_tablet":0,"ocean_menu_typo_spacing_mobile":0,"ocean_menu_typo_spacing_unit":"","ocean_menu_link_color":"","ocean_menu_link_color_hover":"","ocean_menu_link_color_active":"","ocean_menu_link_background":"","ocean_menu_link_hover_background":"","ocean_menu_link_active_background":"","ocean_menu_social_links_bg":"","ocean_menu_social_hover_links_bg":"","ocean_menu_social_links_color":"","ocean_menu_social_hover_links_color":"","ocean_disable_title":"default","ocean_disable_heading":"default","ocean_post_title":"","ocean_post_subheading":"","ocean_post_title_style":"","ocean_post_title_background_color":"","ocean_post_title_background":0,"ocean_post_title_bg_image_position":"","ocean_post_title_bg_image_attachment":"","ocean_post_title_bg_image_repeat":"","ocean_post_title_bg_image_size":"","ocean_post_title_height":0,"ocean_post_title_bg_overlay":0.5,"ocean_post_title_bg_overlay_color":"","ocean_disable_breadcrumbs":"default","ocean_breadcrumbs_color":"","ocean_breadcrumbs_separator_color":"","ocean_breadcrumbs_links_color":"","ocean_breadcrumbs_links_hover_color":"","ocean_display_footer_widgets":"default","ocean_display_footer_bottom":"default","ocean_custom_footer_template":"","footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-6845","page","type-page","status-publish","hentry","entry"],"_links":{"self":[{"href":"https:\/\/www.sim.upb.ro\/index.php\/wp-json\/wp\/v2\/pages\/6845","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.sim.upb.ro\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.sim.upb.ro\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.sim.upb.ro\/index.php\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/www.sim.upb.ro\/index.php\/wp-json\/wp\/v2\/comments?post=6845"}],"version-history":[{"count":10,"href":"https:\/\/www.sim.upb.ro\/index.php\/wp-json\/wp\/v2\/pages\/6845\/revisions"}],"predecessor-version":[{"id":6909,"href":"https:\/\/www.sim.upb.ro\/index.php\/wp-json\/wp\/v2\/pages\/6845\/revisions\/6909"}],"wp:attachment":[{"href":"https:\/\/www.sim.upb.ro\/index.php\/wp-json\/wp\/v2\/media?parent=6845"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}