{"id":6806,"date":"2025-12-02T14:39:31","date_gmt":"2025-12-02T12:39:31","guid":{"rendered":"https:\/\/www.sim.upb.ro\/?page_id=6806"},"modified":"2025-12-09T14:23:27","modified_gmt":"2025-12-09T12:23:27","slug":"magrebone","status":"publish","type":"page","link":"https:\/\/www.sim.upb.ro\/index.php\/magrebone\/","title":{"rendered":"MagReBone"},"content":{"rendered":"\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t

MagReBone <\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t

Titlu proiect: \nImplanturi personalizate din aliaje de magneziu biodegradabile cu suprafa\u021b\u0103 modificat\u0103 pentru regenerare osoas\u0103<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t

Project Title: \nPersonalized implants made by biodegradable magnesium-based alloys with modified surface for bone tissue regeneration.<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t\t\t

\"eng\"<\/a><\/p>

Click here for English<\/a><\/h3>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t\t\t

Acronimul proiectului:<\/strong> MagReBone<\/h3>

Cod proiect: <\/strong>PN-IV-P1-PCE-2023-1452<\/h3>

Nr contractului: <\/strong>95PCE\/01.07.2025<\/h3>

Contractor: <\/strong>UNIVERSITATEA NA\u021aIONAL\u0102 DE \u0218TIIN\u021a\u0102 \u0218I TEHNOLOGIE POLITEHNICA BUCURE\u0218TI<\/h3>

Data \u00eenceperii contractului: <\/strong>01.07.2025<\/h3>

Data \u00eencheierii contractului: <\/strong>30.06.2028<\/h3>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t

Abstract<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t\t\t

Unul dintre cele mai importante concepte din domeniul \u0219tiin\u021bei \u0219i ingineriei materialelor este reprezentat de noile biomateriale utilizate \u00een fabricarea de implanturi dedicate \u0219tiin\u021bei medicale care pot genera un micromediu adecvat diferen\u021bierii celulare \u00eentr-o manier\u0103 controlat\u0103 pentru a regenera \u021besutul deteriorat sau absent.<\/span><\/h3>

Obiectivul principal al proiectului<\/strong> const\u0103 \u00een proiectarea, fabricarea, caracterizarea \u0219i testarea de noi configura\u021bii de implanturi din aliaje pe baz\u0103 de Mg bioactive \u0219i biodegradabile cu geometrie anatomic\u0103 utilizate pentru tratarea defectelor osoase de dimensiuni critice. Pentru atingerea obiectivelor proiectului, am stabilit o strategie de lucru, pe baza experien\u021bei anterioare \u0219i a rezultatelor anterioare ob\u021binute. Principalele elemente de originalitate \u0219i inova\u021bie ale proiectului propus constau \u00een faptul c\u0103 implanturile, care vor fi dezvoltate, vor avea o geometrie similar\u0103 cu cea a osului uman, iar forma lor va fi adaptat\u0103 anatomic. O abordare inovatoare este legat\u0103 de dezvoltarea unei metodologii pentru a optimiza designul implantului din aliaj de Mg pornind de la imagistica medical\u0103 personalizat\u0103, folosind inteligen\u021ba artificial\u0103 \u0219i analiza dinamicii inverse.<\/h3>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t

Rezultatele estimate<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t\t\t

  1. Rapoarte de cercetare \u0219i financiare pentru etapele intermediare \u0219i final\u0103.<\/h3><\/li>

  2. Rapoarte de audit aferente etapelor.<\/h3><\/li>

  3. Cerere de brevet.<\/h3><\/li>

  4. Pagina web a proiectului.<\/h3><\/li>

  5. Software IA pentru segmentare; Proceduri inovatoare pentru identificarea \u0219i segmentarea defectelor osoase; Modele 3D; Design inovator implant; Design inovator de acoperire bioactiv\u0103;<\/h3><\/li>

  6. Design optimizat al implantului.<\/h3><\/li>

  7. Matri\u021be metalice ob\u021binute prin printare 3D, prototipuri de implanturi din aliaje pe baz\u0103 de Mg.<\/h3><\/li>

  8. E\u0219antioane experimentale pentru caracterizare \u0219i testare.<\/h3><\/li>

  9. Prototipuri de implanturi din aliaje pe baz\u0103 de Mg cu acoperire ceramic\u0103 bioactiv\u0103.<\/h3><\/li>

  10. E\u0219antioane experimentale pentru caracterizare \u0219i testare.<\/h3>

    Raport de analiz\u0103 privind biodegradarea prin teste electrochimice.<\/h3><\/li>

  11. Raport de analiz\u0103 privind propriet\u0103\u021bile de suprafa\u021b\u0103.<\/h3><\/li>

  12. Raport de analiz\u0103 privind biodegradarea prin teste de imersie.<\/h3><\/li>

  13. Raport privind biocompatibilitatea in vitro<\/em>.<\/h3><\/li>

  14. Raport privind biocompatibilitatea in vivo<\/em>.<\/h3><\/li>

  15. Rapoarte de diseminare a rezultatelor cercetarii (articole, prezentari la conferinte).<\/h3><\/li><\/ol>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
    \n\t\t\t\t\t\t
    \n\t\t\t\t\t
    \n\t\t\t
    \n\t\t\t\t\t\t
    \n\t\t\t\t
    \n\t\t\t\t\t

    Plan de lucru<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
    \n\t\t\t\t\t\t
    \n\t\t\t\t\t
    \n\t\t\t
    \n\t\t\t\t\t\t
    \n\t\t\t\t
    \n\t\t\t\t\t\t\t\t\t

    Etapa I\/31.12.2025<\/strong> – Proiectarea implanturilor din aliaje pe baz\u0103 de magneziu<\/h3>

    Etapa II\/30.12.2026<\/strong> – Obtinerea implanturilor din aliaje pe baz\u0103 de magneziu. Caracterizarea microstructural\u0103 pentru implanturile din aliaje pe baz\u0103 de magneziu.<\/h3>

    Etapa III\/31.12.2027<\/strong> – Evaluarea propriet\u0103\u021bilor mecanice, a propriet\u0103\u021bilor de suprafa\u021b\u0103 \u0219i a comportamentului la coroziune prin metode electrochimice.<\/h3>

    Etapa IV\/30.06.2028<\/strong> – Evaluarea comportamentului la biodegradare prin teste de imersie a implanturilor ob\u021binute din aliaje pe baz\u0103 de magneziu. Evaluarea in vivo<\/em> a biocompatibilit\u0103\u021bii implanturilor din aliaje pe baz\u0103 de magneziu.<\/h3>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
    \n\t\t\t\t\t\t
    \n\t\t\t\t\t
    \n\t\t\t
    \n\t\t\t\t\t\t
    \n\t\t\t\t
    \n\t\t\t\t\t

    Rezultate Etapa 1:<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
    \n\t\t\t\t\t\t
    \n\t\t\t\t\t
    \n\t\t\t
    \n\t\t\t\t\t\t
    \n\t\t\t\t
    \n\t\t\t\t\t\t\t\t\t

    Software IA pentru segmentare. Proceduri inovatoare pentru identificarea \u0219i segmentarea defectelor osoase. Modele 3D. Design inovator implant. Design inovator de acoperire bioactiv\u0103. Baz\u0103 de date. Design optimizat al implantului. E\u0219antioane experimentale. Raport de testare.<\/h3>\n

    Cerere brevet de inven\u021bie A\/00592\/04.12.2025, cu titlul: <\/span>Metod\u0103 de elaborare a unui implant poros din aliaj de magneziu cu acoperire bioactiv\u0103<\/b><\/span><\/h3>\n

    Pagina web a proiectului: <\/span>https:\/\/www.sim.upb.ro\/index.php\/magrebone\/<\/strong><\/a><\/h3>\n

    1 lucrare ISI:\nSuitability of Mg-Nd and Mg-Zn Alloys to Obtain Biodegradable Structures for Bone Defects,Veronica Manescu (Paltanea), Aurora Antoniac, Maria Cristina Moraru, Cosmin Mihai Cotrut, Iulian Antoniac, Sebastian Gradinaru, Alexandra Iulia Dreanca, Bogdan Sevastre, Romelia Pop, Flaviu Alexandru Tabaran, George Mihail Vlasceanu, Mariana Ionita, Marius Manole, J. Funct. Biomater. 2025, 16(11), 423; <\/span>https:\/\/doi.org\/10.3390\/jfb16110423<\/a> (FI = 5,2)<\/span>\n<\/span><\/h3>\n

    2 comunic\u0103ri orale \u0219i 3 comunic\u0103ri sub form\u0103 de poster la conferin\u021be interna\u021bionale:<\/span><\/h3>\n
      \n \t
    1. \n

      Effect of the testing media on the degradation of magnesium-based alloys potentially used for bone defect treatments<\/em>, Voicu Ioan \u0218tefan, Corneschi Iuliana, Antoniac Aurora, Pieptea (Popescu) Elena, Antoniac Iulian, Advances in 3OM: Opto-Mechatronics, Opto-Mechanics, and Optical Metrology and Photonics Technologies<\/em>, 08-11 decembrie 2025, Timi\u0219oara, Romania \u2013 POSTER PRESENTATION<\/strong><\/h3>\n<\/li>\n \t
    2. \n

      Biomaterials and Medical Devices in Tomorrow\u2019s Healthcare<\/em>, Iulian Vasile Antoniac, Advances in 3OM: Opto-Mechatronics, Opto-Mechanics, and Optical Metrology and Photonics Technologies<\/em>, 08-11 decembrie 2025, Timisoara, Romania \u2013 KEYNOTE PRESENTATION<\/strong><\/h3>\n<\/li>\n \t
    3. \n

      Evaluation of The Cellulose-Acetate-Based Composite Used as Coatings for Biodegradable Magnesium Implants<\/em>, Streza Alexandru, Antoniac Aurora, Voicu Ioan Stefan, Paltanea (Manescu) Veronica, Popescu Elena, Antoniac Iulian, 4th INTERNATIONAL MATERIALS TECHNOLOGIES AND METALLURGY CONFERENCE,<\/em> 02-03 octombrie 2025, Istanbul, Turcia \u2013 ORAL PRESENTATION<\/strong><\/h3>\n<\/li>\n \t
    4. \n

      Mg-Zn biodegradable alloy as a suitable material for bone defect,<\/em> Veronica Manescu (Paltanea), Iulian Antoniac, Aurora Antoniac, Alexandru Streza, Sebastian Gradinaru, Maria-Cristina Moraru, Bogdan Sevastre, Marius Manole, International Conference on Biomaterials & Regenerative Medicine BioREMED\u20192025, <\/em>16-18 octombrie 2025, Oradea, Romania \u2013 POSTER PRESENTATION<\/strong><\/h3>\n<\/li>\n \t
    5. \n

      Structural modifications induced by plastic deformation in the case of biodegradable magnesium alloys from Mg-Zn-Mn-Ca system<\/em>, Elena Pieptea (Popescu), Iuliana Corneschi, Aurora Antoniac, Nicolae Serban, Marian Miculescu, Iulian Antoniac, 6th International Conference on Powder Metallurgy & Advanced Materials<\/em>, 29 octombrie – 01 noiembrie 2025, Cluj-Napoca, Romania \u2013 POSTER PRESENTATION<\/strong>, lucrarea a primit premiul Best Poster Presentation<\/em><\/h3>\n<\/li>\n<\/ol>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

      MagReBone Titlu proiect: Implanturi personalizate din aliaje de magneziu biodegradabile cu suprafa\u021b\u0103 modificat\u0103 pentru regenerare osoas\u0103 Project Title: Personalized implants made by biodegradable magnesium-based alloys with modified surface for bone tissue regeneration. Click here for English Acronimul proiectului: MagReBone Cod proiect: PN-IV-P1-PCE-2023-1452 Nr contractului: 95PCE\/01.07.2025 Contractor: UNIVERSITATEA NA\u021aIONAL\u0102 DE \u0218TIIN\u021a\u0102 \u0218I TEHNOLOGIE POLITEHNICA BUCURE\u0218TI Data […]<\/p>\n","protected":false},"author":4,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"ocean_post_layout":"","ocean_both_sidebars_style":"","ocean_both_sidebars_content_width":0,"ocean_both_sidebars_sidebars_width":0,"ocean_sidebar":"","ocean_second_sidebar":"","ocean_disable_margins":"enable","ocean_add_body_class":"","ocean_shortcode_before_top_bar":"","ocean_shortcode_after_top_bar":"","ocean_shortcode_before_header":"","ocean_shortcode_after_header":"","ocean_has_shortcode":"","ocean_shortcode_after_title":"","ocean_shortcode_before_footer_widgets":"","ocean_shortcode_after_footer_widgets":"","ocean_shortcode_before_footer_bottom":"","ocean_shortcode_after_footer_bottom":"","ocean_display_top_bar":"default","ocean_display_header":"default","ocean_header_style":"","ocean_center_header_left_menu":"","ocean_custom_header_template":"","ocean_custom_logo":0,"ocean_custom_retina_logo":0,"ocean_custom_logo_max_width":0,"ocean_custom_logo_tablet_max_width":0,"ocean_custom_logo_mobile_max_width":0,"ocean_custom_logo_max_height":0,"ocean_custom_logo_tablet_max_height":0,"ocean_custom_logo_mobile_max_height":0,"ocean_header_custom_menu":"","ocean_menu_typo_font_family":"","ocean_menu_typo_font_subset":"","ocean_menu_typo_font_size":0,"ocean_menu_typo_font_size_tablet":0,"ocean_menu_typo_font_size_mobile":0,"ocean_menu_typo_font_size_unit":"px","ocean_menu_typo_font_weight":"","ocean_menu_typo_font_weight_tablet":"","ocean_menu_typo_font_weight_mobile":"","ocean_menu_typo_transform":"","ocean_menu_typo_transform_tablet":"","ocean_menu_typo_transform_mobile":"","ocean_menu_typo_line_height":0,"ocean_menu_typo_line_height_tablet":0,"ocean_menu_typo_line_height_mobile":0,"ocean_menu_typo_line_height_unit":"","ocean_menu_typo_spacing":0,"ocean_menu_typo_spacing_tablet":0,"ocean_menu_typo_spacing_mobile":0,"ocean_menu_typo_spacing_unit":"","ocean_menu_link_color":"","ocean_menu_link_color_hover":"","ocean_menu_link_color_active":"","ocean_menu_link_background":"","ocean_menu_link_hover_background":"","ocean_menu_link_active_background":"","ocean_menu_social_links_bg":"","ocean_menu_social_hover_links_bg":"","ocean_menu_social_links_color":"","ocean_menu_social_hover_links_color":"","ocean_disable_title":"default","ocean_disable_heading":"default","ocean_post_title":"","ocean_post_subheading":"","ocean_post_title_style":"","ocean_post_title_background_color":"","ocean_post_title_background":0,"ocean_post_title_bg_image_position":"","ocean_post_title_bg_image_attachment":"","ocean_post_title_bg_image_repeat":"","ocean_post_title_bg_image_size":"","ocean_post_title_height":0,"ocean_post_title_bg_overlay":0.5,"ocean_post_title_bg_overlay_color":"","ocean_disable_breadcrumbs":"default","ocean_breadcrumbs_color":"","ocean_breadcrumbs_separator_color":"","ocean_breadcrumbs_links_color":"","ocean_breadcrumbs_links_hover_color":"","ocean_display_footer_widgets":"default","ocean_display_footer_bottom":"default","ocean_custom_footer_template":"","footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-6806","page","type-page","status-publish","hentry","entry"],"_links":{"self":[{"href":"https:\/\/www.sim.upb.ro\/index.php\/wp-json\/wp\/v2\/pages\/6806","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.sim.upb.ro\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.sim.upb.ro\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.sim.upb.ro\/index.php\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/www.sim.upb.ro\/index.php\/wp-json\/wp\/v2\/comments?post=6806"}],"version-history":[{"count":36,"href":"https:\/\/www.sim.upb.ro\/index.php\/wp-json\/wp\/v2\/pages\/6806\/revisions"}],"predecessor-version":[{"id":6871,"href":"https:\/\/www.sim.upb.ro\/index.php\/wp-json\/wp\/v2\/pages\/6806\/revisions\/6871"}],"wp:attachment":[{"href":"https:\/\/www.sim.upb.ro\/index.php\/wp-json\/wp\/v2\/media?parent=6806"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}